For by Him were all things created, that are in heaven, and that are in earth, visible and invisible,...For the invisible things of Him from the creation of the world are clearly seen, being understood by the things that are made, ...so that THEY ARE WITHOUT EXCUSE: Col 1:16 / Rom.1:20
Showing posts with label Chromatin. Show all posts
Showing posts with label Chromatin. Show all posts

Saturday, February 1, 2025

Contained in EVERY Cell

 Thank You for making me so wonderfully complex!
Your workmanship is marvelous—how well I know it. 
Psalm 139:14 NLT

"Every cell in your body 
---contains the same genetic sequence, 
---yet each cell expresses only a subset of those genes. 

These cell-specific gene expression patterns, which ensure that a
brain cell is different from a skin cell, are partly determined by the three-dimensional structure of the genetic material, which controls the accessibility of each gene.


Inside the cell nucleus, DNA and proteins form a complex called chromatin, which has several levels of organization, 
---allowing cells to cram 2 meters of DNA into a nucleus that is only one-hundredth of a millimeter in diameter. 
Long strands of DNA wind around proteins called histones, giving rise to a structure somewhat like beads on a string.

Chemical tags known as epigenetic modifications can be attached to DNA at specific locations, and these tags, which vary by cell type, affect the folding of the chromatin and the accessibility of nearby genes. 
These differences in chromatin conformation help determine which genes are expressed in different cell types, or at different times within a given cell." 
Phys.org

Saturday, January 27, 2024

Your "Internet Search Engine"

"In addition to DNA methylation and histone modifications, scientists have discovered a powerful epigenetic system that operates on top of the genetic code in a very different way from being chemically attached to the chromatin itself. 
(DNA complexed with histones is called chromatin.)

This amazing epigenetic paradigm is associated with very small
RNA molecules that are heritable and that profoundly and adaptively affect the development of an organism’s offspring.

One of the best ways to describe how small RNAs work in the cell is to use the analogy of an internet search engine. When a search engine is pulled up in your web browser, you can type in a small bit of text, hit enter, and then get a hit wherever the text matches up. For example, you could enter “for God so loved the world,” and it would immediately pull up the Bible verse John 3:16."
ICR